Category Archives: Uncategorized

So, How Many R01s is Too Many?

Some around the interwebz have responded with displeasure at my recent tweet that a scientist with 8 R01s is going to be visiting my MRU in the near future.  It apprears to me that there is a subtle difference between enough and too many. Apparently 8 R01s is too many.

So, what number is the right and equitable number of R01s for a lab to have?

Because It Sets A Bad Precedent…

I have settled in for the night to review a paper and, to be honest, I am feeling some kind of way about it…

A couple of years ago I submitted a paper to a journal and got what I believed to be a bullshit review. I must have been living a charmed life until that point because I had never had an experience like this. I emailed the associate editor and made my case that these reviewers clearly had phoned it in. She was gracious and wrote me a long note explaining how it would send a bad precedent if the associate editor started second guessing the reviewers’ recommendations. I relented, submitted the work elsewhere and it was accepted.

So, imagine my surprise when I received a request to review a couple of weeks ago with a note from the same associate editor. I had recommended rejection of a previous review and she stated that, although the reviewers had not been enthusiastic about the work, the authors made a strong case for reconsideration and she believed that they could satisfy the reviewers with this resubmission.

A bad precedent, indeed.

Struggles of the Scientific Riff-Raff

I have a grant due on the 3rd. It’s a smallish, sort of medium-sized grant that would allow us to add some supplementary studies to our current model. The blessing and the curse it that it’s only 1.75 pages. One would think that I could get my shit together to write 1.75 pages but, as with other things in my life, the smaller it is the harder it is for me to get it finished.

If you head over to Drugmonkey’s joint and read the comments of ASBMB president Steven McKnight, you might conclude that I am a member of the scientific #riffraff – less talented and creative than my predecessors in previous generations. Maybe that’s why these 1.75 pages are so damned hard to write.  After all, “ the average scientist today is not of the quality of our predecessors… Biomedical research is a huge enterprise now; it attracts riff-raff who never would have survived as scientists in the 1960s and 1970s.”

I should be able to have big ideas and big dreams and be able to easily communicate my wispy, truthy sounding ideas in that short amount of space.

Or, maybe the game has gotten so hard because the rules continue to change in unpredictable ways. Back in the 60s and 70s, a bunch of old, white dudes held the keys to the club. They knew each other and gave out money to the gentleman, renaissance scientists they knew and their big, innovative ideas.  But, the probability of funding was different, both because of the number of people and the breadth of fields, and its easier to split pie when there are fewer mouth to feed.

Now, I find myself with a damned conundrum. Having written R-type grants, I know that the ones most likely to be funded are the ones solidly rooted in pilot and feasibility data.  I understand that it’s important to sell the notion that the shit will really work and “Do you know who I am” doesn’t get a gal as far as it used to. The proof-of-success strategy worked for a time being, to be sure.  Yet, there are also awards that hint at a desire to get back to this renaissance scientist notion - the NIH is trying to be hip and edgy, funding people and their high risk, highly innovative ideas. Allegedly. I remain skeptical of our commitment to new and edgy when the pot feels so small. When people tell me “be innovative and pilot data be damned”, I feel like a puppy whose nose has been hit too many times.

But, this is the easily predictable outcome when you expand the number of areas of research that you label “important” in excess of the amount of money you pour in and it means that we’ve taken to eating our young. I would remind the esteemed and noble Dr. McKnight that he and his ilk produced us riff-raff. Empires were built on the shoulders of a large number of trainees. Perhaps the error was in making the number of faculty trainees one generated a milestone of success. None of us trained ourselves and now that the next scientific generation(s) poses a threat to the established greybeardatariot, it’s time to get offa their lawn.  Dr. McKnight lists 40 riff-raff scientists that he has trained. Where did he think they were going to go? Where were they going to get money from? Who does he think is making up the society that he allegedly steers?

Perhaps at the core of his discontent is the fact that there simply isn’t enough money to go around to do science the way McKnight would have it done. He writes on his lab website:

…how might a young scientist pursue this course and decide what to do? The actual choice of direction is the easiest problem to solve. One simply has to look where the trends are headed and go the other way. Here, for conceptual purposes only, I suggest a “pin the tail on the donkey” approach. A randomly assembled chart is printed up containing squares labeled with all of our 20 to 30 thousand genes. Of these, we know lots about some, a bit about others, yet almost nothing of the remainder. We slap on a blindfold then throw the dart against the wall. Chances are reasonably good that the dart will land on an “unknown” gene—as long as the contestant does not peek around the blindfold and aim the dart at the squares adorned with the comfortable names that already appear every day in the literature. That the unknown gene does something critical is supported by the fact that it’s been kept in place by hundreds of millions of years of evolution. That every gene and every protein are both interesting and important is incontrovertible. This being the case, why would anyone want to work on a gene or protein already staked out by dozens of other scientists?

Individual scientist, toiling away in their lab, each working in parallel on some randomly selected bit of the scientific enterprise simply for the discovery of science’s “mystic state [his words]“.  Then how does one judge merit for entrance into the priesthood and eligibility for future funding? The way it was done when Dr. McKnight was a wee lad – by maintaining a club of well-connected, similar individuals with similar goals and attitudes.

I’d much rather be a member of the riff-raff.

romymichelle

That, My Darlings, Is Not Irony…It’s Just a Waste of Time

I don’t consider myself to typically be a member of the grammar police, but misuse of the word “irony” really chaps my ass in some kind of special way. I mean, you can be a dumb ass about any other component of the English and I will literally feel nothing. Literally.

irony

When I left my old MRU, I left a bunch of things and took a bunch of things. I kept some collaborations and I parted with some collaborations. One of the collaborations I parted with involved a particularly difficult (in my view) set of measurements. When I developed them, it took a year of mistakes to finally realize all of the important steps to collecting good data. I offered help to the group to get things up and running, providing they acted within a time frame that didn’t impair my own productivity.  They deferred and the head of the group told me that she was sure that, if I could do it, someone else could surely figure it out. I didn’t disagree, but did note the amount of time it had taken me to develop things from square one. But, I mic dropped and headed on my way.

mic drop2

These measurements are the bred and butter of my program, though, and I have have been spending some time recapitulating the setup in my new lab. Today I spoke with one of the vendors about a purchase and she remarked…

How ironic! [Our tech support person] was just at your old MRU seeing if he could help another group through some trouble they’re having and figure out how to ]make these measurements with this equipment]!

My friends, that is not ironic at all. Irony requires a reversal of expectations. It may be like a traffic jam when you’re already late, but it is certainly not irony.

Which brings me to my absolute biggest pet peeve about the way some trainees embark upon a new scientific endeavor. The one lesson that I have not been able to impart upon anyone thus far is, when you’re trying to implement a new non-commercial technique or establish a model, have a conversation with the people that have already done it. Our field is not generally one where experiments are easily scooped by others. If you get scooped, it’s usually because a project took months to years longer than it should have.

I’ve had people spectacularly waste more time dicking around, thinking they could get stuff  to work, than I’ve had stuff scooped because I let another group know what direction I was thinking. I don’t know if it’s hubris that people think that recapitulating a technique will be easy, or too much faith in the completeness of methods sections in the scientific literature, or fear of contacting other scientists.

I don’t know what it is, but I do know that it wastes time and resources. It’s no skin off my nose if another group does it, but I have got to figure out a way to get people in my group to not establish this time and money wasting M.O. Literally.

The Fine Art of the Rubber Stamp

It’s an awkward situation when you’ve identified issues with a PhD candidate’s experiments…you tell them that you should meet to discuss some of these issues and how to solve them…then months or years go by and you don’t hear from them..

…until you get an email about scheduling their defense..

Where do I sign?